Treating serious mental illness by addressing metabolic dysfunction — not masking symptoms.

Evidence-based ketogenic and metabolic therapies for bipolar disorder, schizophrenia. severe depression, and treatment-resistant mental illness.

ABOUT

Dr. Kirollus Nagi

I am a nutritional pharmacist and mental health counselor working at the intersection of pharmacology, functional medicine, and metabolic psychiatry, with a clinical focus on brain–body metabolism.

My work focuses on severe and treatment-resistant mental illnesses — including bipolar disorder, schizophrenia, and treatment resistant depression — using a biological framework that understands mental illness, in part, as a disorder of brain energy metabolism.

I apply ketogenic and metabolic therapies within a functional medicine model, integrating nutrition, metabolism, and individualized biochemical assessment, while remaining grounded in pharmacological knowledge and clinical safety.

All interventions are applied within a structured clinical context, with respect for psychiatric care, medication management, and the broader psychological dimensions of mental illness.

Pharmacology · Functional Medicine · Metabolic Psychiatry

Professional Training & Certifications

Selected clinical and professional training in pharmacy, functional nutrition, metabolic psychiatry, and addiction treatment

Bachelor of
Pharmacy

Bachelor of Pharmacy

Ain Shams University

2022

Ketogenic Diets for Mental Health

Clinical Training – Dr. Georgia Ede

2026

Scope Certification in Nutrition & Weight Management

World Obesity Federation

2025

International Substance Abuse & Addiction Counseling

Professional Training Program

2025

Understand the Problem

A biological framework for understanding severe mental illness — beyond symptom management.

The Problem

For decades, severe mental illnesses such as bipolar disorder and schizophrenia were viewed as chronic, relentless brain diseases that required lifelong use of psychiatric medications.

Depression, on the other hand, was framed as a simple chemical imbalance, supposedly correctable through antidepressants such as SSRIs.

This model shaped what became known as classic psychiatry — an approach that focused primarily on symptom management, rather than addressing the underlying biological dysfunction.

As a result, psychiatric treatment often aimed to mask symptoms, not resolve their root cause.

What Classic Psychiatry Failed to Address

Growing scientific evidence now shows that many psychiatric disorders are associated with impaired brain energy metabolism, driven by fundamental biological dysfunctions, including:

  • mitochondrial dysfunction
  • chronic neuroinflammation
  • insulin resistance and glucose dysregulation
  • high oxidative stress

The brain is the most energy-demanding organ in the human body.

When energy production inside the mitochondria is compromised, brain function becomes unstable — leading to the wide range of symptoms we classify as mental illness.

In this context, psychiatric symptoms are not isolated events, but downstream expressions of a failing metabolic system.

The Solution

If mental illness is, in part, a disorder of brain energy metabolism, then treatment must address how the brain is fueled.

This is the foundation of metabolic psychiatry.

Metabolic psychiatry focuses on interventions that aim to:

  • reduce neuroinflammation
  • stabilize brain energy production
  • improve mitochondrial efficiency
  • restore metabolic flexibility

The Role of the Therapeutic Ketogenic Diet

One of the most powerful tools within this framework is the therapeutic ketogenic diet.

By shifting the brain’s primary fuel from glucose to ketones, ketogenic metabolic therapies can:

  • bypass impaired glucose metabolism
  • provide a more efficient and stable energy source for neurons
  • reduce oxidative stress and inflammation

When applied clinically, and combined with:

  • professional psychotherapy that reduces chronic stress
  • lifestyle interventions that improve overall metabolic health

real and measurable improvement in severe mental illness begins to occur.

This is not symptom masking.

This is biological repair.

Comprehensive Metabolic Recovery Program

A complete, intensive treatment program designed to address mental illness through a holistic medical framework/ integrating the science of metabolic psychiatry and functional medicine.

This program is built to target both the physiological and psychological roots of mental illness, not merely-manage symptoms.

Why an Intensive, Holistic Approach Matters

Severe mental illnesses are not isolated brain disorders. They are systemic conditions driven by chronic metabolic stress, neuroinflammation, and impaired energy prodüction in the brain.

Chronic psychological stress plays a central role in this process.

  • Prolonged stress increases the brain’s energy demands, overwhelms mitochondrial capacity, and activates inflammatory pathways — eventually leading to symptom expression such as mood instablity, anxiety, depression, and psychosis.

For this reason, effective treatment must address:

  • brain energy metabolism
  • inflammation
  • nutritional status
  • psychological stress regulation

This program is designed to do exactly that.

Client Testimonials

Articles

Social Media

FAQs

No. This program is not the popular keto diet used for weight loss on social media.

What is applied here is therapeutic ketogenic therapy, a medical intervention designed to target brain energy metabolism—not body weight.

There is a major difference between:

  • Nutritional ketosis (common in lifestyle or weight-loss keto), and
  • Therapeutic or deep ketosis, which is used clinically to influence brain function, inflammation, and mitochondrial energy production.

Therapeutic ketosis involves:

  • deeper and more stable ketone levels
  • careful clinical monitoring
  • individualized protocols
  • safety considerations specific to psychiatric conditions

This is not a diet trend. It is a structured medical approach used in neurological and psychiatric contexts.

Psychiatric medications are not usually adjusted during the early phase of therapeutic ketogenic therapy.

In most cases:

  • Medications are kept stable during the first 3 months, while metabolic adaptation and clinical stability are carefully monitored.
  • This initial period allows the brain to adjust to therapeutic ketosis without introducing multiple variables at once.

There are specific medications that may require early attention or adjustment due to known metabolic interactions or safety considerations.

When this is necessary, it is addressed carefully and on a case-by-case basis.

If medication reduction is considered, the process typically begins after the third month, and only when:

  • sustained clinical stability is observed
  • the individual is metabolically stable
  • there is clear medical justification

Medication tapering is:

  • slow and gradual
  • based on hyperbolic tapering principles
  • individualized, not protocol-driven
  • conducted under full medical supervision

Medications are never stopped abruptly, and no changes are made independently or without coordination with the treating physician.

No. This program is not anti-psychiatry, and it is not opposed to psychiatric medications in general.

Psychiatric medications can play an important role, particularly:

  • during acute phases
  • for crisis stabilization
  • when symptoms are severe or disabling

There is room for medication use, especially in the short term, when it is clinically justified.

However, this program takes a clear position against the long-term, indefinite use of medications as a sole strategy, when they are used only to suppress symptoms without addressing the underlying biological dysfunction.

Long-term reliance on medications alone may:

  • mask symptoms rather than treat root causes
  • delay metabolic and neurological recovery
  • limit the brain’s ability to regain resilience

In addition, certain medications—such as SSRIs—can blunt emotional processing, which may interfere with the depth and effectiveness of psychotherapy, particularly when emotional integration is a key part of healing.

For these reasons, this program is not anti-psychiatry—but it is against the inappropriate, prolonged use of medications in a way that hinders recovery rather than supports it.

The goal is collaboration, not opposition:

  • medications when needed
  • metabolic and biological repair as the foundation
  • psychotherapy when emotional processing is possible and meaningful

This program is designed for individuals who feel that conventional psychiatric approaches have failed them, and who are seeking a different, biology-focused, root cause approach to recovery.

It is particularly suited for people whose conditions have been labeled as:

  • “chronic”
  • “lifelong”
  • “requiring permanent medication”

and who continue to experience significant symptoms despite standard treatment.

The program may be appropriate for individuals diagnosed with:

  • bipolar disorder
  • schizophrenia
  • treatment-resistant depression
  • severe anxiety disorders
  • relentless or treatment-resistant OCD
  • other forms of severe mental illness

This approach is for those who are not satisfied with symptom management alone, and who are looking to address root biological factors, particularly brain energy metabolism and systemic dysfunction.

If you feel that modern psychiatry has reached its limits in your case—and you are seeking a new, structured, and evidence-informed approach—this program may be appropriate for you.

This is not a quick fix or an experimental shortcut.

It is a serious intervention for individuals ready to engage in a deep, long-term recovery process.

Still have questions?